Publications

Stack of books

2021

  • Go CD, Knight JDR, Rajasekharan A, Rathod B, Hesketh GG, Abe KT, Youn JY, Samavarchi-Tehrani P, Zhang H, Zhu LY, Popiel E, Lambert JP, Coyaud É, Cheung SWT, Rajendran D, Wong CJ, Antonicka H, Pelletier L, Palazzo AF, Shoubridge EA, Raught B and Gingras AC. A proximity-dependent biotinylation map of a human cell. Nature. 2021. PMID: 34079125.
  • Piette BL, Alerasool N, Lin ZY, Lacoste J, Lam MHY, Qian WW, Tran S, Larsen B, Campos E, Peng J, Gingras AC and Taipale M. Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains. Mol Cell. 2021. PMID: 33957083.
  • Merritt N, Garcia K, Rajendran D, Lin ZY, Zhang X, Mitchell KA, Borcherding N, Fullenkamp C, Chimenti MS, Gingras AC, Harvey KF and Tanas MR. TAZ-CAMTA1 and YAP-TFE3 alter the TAZ/YAP transcriptome by recruiting the ATAC histone acetyltransferase complex. Elife. 2021. PMID: 33913810.
  • Azad T, Singaravelu R, Taha Z, Jamieson TR, Boulton S, Crupi MJF, Martin NT, Brown EEF, Poutou J, Ghahremani M, Pelin A, Nouri K, Rezaei R, Marshall CB, Enomoto M, Arulanandam R, Alluqmani N, Samson R, Gingras AC, Cameron DW, Greer PA, Ilkow CS, Diallo JS and Bell JC. Nanoluciferase complementation-based bioreporter reveals the importance of N-linked glycosylation of SARS-CoV-2 S for viral entry. Mol Ther. 2021, 29(6): 1984-2000. PMID: 33578036.
  • Hirst J, Hesketh GG, Gingras AC and Robinson MS. Rag GTPases and phosphatidylinositol 3-phosphate mediate recruitment of the AP-5/SPG11/SPG15 complex. J Cell Biol. 2021. PMID: 33464297.
  • Khan KA, Marineau A, Doyon P, Acevedo M, Durette É, Gingras AC and Servant MJ. TRK-Fused Gene (TFG), a protein involved in protein secretion pathways, is an essential component of the antiviral innate immune response. PLoS Pathog. 2021, 17(1): e1009111. PMID: 33411856.
  • Kawashima AT, Wong C, Lordén G, King CC, Lara-Gonzalez P, Desai A, Gingras AC and Newton AC. The PHLPP1 N-Terminal Extension is a Mitotic Cdk1 Substrate and Controls an Interactome Switch. Mol Cell Biol. 2021. PMID: 33397691.
  • Kim SH, Choi JH, Wang P, Go CD, Hesketh GG, Gingras AC, Jafarnejad SM and Sonenberg N. Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation. Mol Cell. 2021, 81(2): 398-407.e4. PMID: 33340489.
  • Law JC, Koh WH, Budylowski P, Lin J, Yue F, Abe KT, Rathod B, Girard M, Li Z, Rini JM, Mubareka S, McGeer A, Chan AK, Gingras AC, Watts TH and A Ostrowski M. Systematic Examination of Antigen-Specific Recall T Cell Responses to SARS-CoV-2 versus Influenza Virus Reveals a Distinct Inflammatory Profile. J Immunol. 2021, 206(1): 37-50. PMID: 33208459.

2020

  • Hesketh GG, Papazotos F, Pawling J, Rajendran D, Knight JDR, Martinez S, Taipale M, Schramek D, Dennis JW and Gingras AC. The GATOR-Rag GTPase pathway inhibits mTORC1 activation by lysosome-derived amino acids. Science. 2020, 370(6514): 351-356. PMID: 33060361.
  • Isho B, Abe KT, Zuo M, Jamal AJ, Rathod B, Wang JH, Li Z, Chao G, Rojas OL, Bang YM, Pu A, Christie-Holmes N, Gervais C, Ceccarelli D, Samavarchi-Tehrani P, Guvenc F, Budylowski P, Li A, Paterson A, Yue FY, Marin LM, Caldwell L, Wrana JL, Colwill K, Sicheri F, Mubareka S, Gray-Owen SD, Drews SJ, Siqueira WL, Barrios-Rodiles M, Ostrowski M, Rini JM, Durocher Y, McGeer AJ, Gommerman JL and Gingras AC. Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients. Sci Immunol. 2020. PMID: 33033173.
  • Tsatskis Y, Rosenfeld R, Pearson JD, Boswell C, Qu Y, Kim K, Fabian L, Mohammad A, Wang X, Robson MI, Krchma K, Wu J, Gonçalves J, Hodzic D, Wu S, Potter D, Pelletier L, Dunham WH, Gingras AC, Sun Y, Meng J, Godt D, Schedl T, Ciruna B, Choi K, Perry JRB, Bremner R, Schirmer EC, Brill JA, Jurisicova A and McNeill H. The NEMP family supports metazoan fertility and nuclear envelope stiffness. Sci Adv. 2020, 6(35): eabb4591. PMID: 32923640.
  • Tao H, Lambert JP, Yung TM, Zhu M, Hahn NA, Li D, Lau K, Sturgeon K, Puviindran V, Zhang X, Gong W, Chen XX, Anderson G, Garry DJ, Henkelman RM, Sun Y, Iulianella A, Kawakami Y, Gingras AC, Hui CC and Hopyan S. IRX3/5 regulate mitotic chromatid segregation and limb bud shape. Development. 2020. PMID: 32907847.
  • Antonicka H, Lin ZY, Janer A, Aaltonen MJ, Weraarpachai W, Gingras AC and Shoubridge EA. A High-Density Human Mitochondrial Proximity Interaction Network. Cell Metab. 2020, 32(3): 479-497.e9. PMID: 32877691.
  • Abe KT, Li Z, Samson R, Samavarchi-Tehrani P, Valcourt EJ, Wood H, Budylowski P, Dupuis AP 2nd, Girardin RC, Rathod B, Wang JH, Barrios-Rodiles M, Colwill K, McGeer AJ, Mubareka S, Gommerman JL, Durocher Y, Ostrowski M, McDonough KA, Drebot MA, Drews SJ, Rini JM and Gingras AC. A simple protein-based surrogate neutralization assay for SARS-CoV-2. JCI Insight. 2020. PMID: 32870820.
  • Posternak G, Tang X, Maisonneuve P, Jin T, Lavoie H, Daou S, Orlicky S, Goullet de Rugy T, Caldwell L, Chan K, Aman A, Prakesch M, Poda G, Mader P, Wong C, Maier S, Kitaygorodsky J, Larsen B, Colwill K, Yin Z, Ceccarelli DF, Batey RA, Taipale M, Kurinov I, Uehling D, Wrana J, Durocher D, Gingras AC, Al-Awar R, Therrien M and Sicheri F. Functional characterization of a PROTAC directed against BRAF mutant V600E. Nat Chem Biol. 2020, 16(11): 1170-1178. PMID: 32778845.
  • Kim DK, Knapp JJ, Kuang D, Chawla A, Cassonnet P, Lee H, Sheykhkarimli D, Samavarchi-Tehrani P, Abdouni H, Rayhan A, Li R, Pogoutse O, Coyaud É, van der Werf S, Demeret C, Gingras AC, Taipale M, Raught B, Jacob Y and Roth FP. A Comprehensive, Flexible Collection of SARS-CoV-2 Coding Regions. G3 (Bethesda). 2020, 10(9): 3399-3402. PMID: 32763951.
  • Aregger M, Lawson KA, Billmann M, Costanzo M, Tong AHY, Chan K, Rahman M, Brown KR, Ross C, Usaj M, Nedyalkova L, Sizova O, Habsid A, Pawling J, Lin ZY, Abdouni H, Wong CJ, Weiss A, Mero P, Dennis JW, Gingras AC, Myers CL, Andrews BJ, Boone C and Moffat J. Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. Nat Metab. 2020, 2(6): 499-513. PMID: 32694731.
  • Abu-Thuraia A, Goyette MA, Boulais J, Delliaux C, Apcher C, Schott C, Chidiac R, Bagci H, Thibault MP, Davidson D, Ferron M, Veillette A, Daly RJ, Gingras AC, Gratton JP and Côté JF. AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network. Nat Commun. 2020, 11(1): 3586. PMID: 32681075.
  • Maiti P, Antonicka H, Gingras AC, Shoubridge EA and Barrientos A. Human GTPBP5 (MTG2) fuels mitoribosome large subunit maturation by facilitating 16S rRNA methylation. Nucleic Acids Res. 2020, 48(14): 7924-7943. PMID: 32652011.
  • Wigington CP, Roy J, Damle NP, Yadav VK, Blikstad C, Resch E, Wong CJ, Mackay DR, Wang JT, Krystkowiak I, Bradburn DA, Tsekitsidou E, Hong SH, Kaderali MA, Xu SL, Stearns T, Gingras AC, Ullman KS, Ivarsson Y, Davey NE and Cyert MS. Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling. Mol Cell. 2020, 79(2): 342-358.e12. PMID: 32645368.
  • St-Germain JR, Samavarchi Tehrani P, Wong C, Larsen B, Gingras AC and Raught B. Variability in Streptavidin-Sepharose Matrix Quality Can Significantly Affect Proximity-Dependent Biotinylation (BioID) Data. J Proteome Res. 2020, 19(8): 3554-3561. PMID: 32628020.
  • Szewczyk MM, Ishikawa Y, Organ S, Sakai N, Li F, Halabelian L, Ackloo S, Couzens AL, Eram M, Dilworth D, Fukushi H, Harding R, Dela Seña CC, Sugo T, Hayashi K, McLeod D, Zepeda C, Aman A, Sánchez-Osuna M, Bonneil E, Takagi S, Al-Awar R, Tyers M, Richard S, Takizawa M, Gingras AC, Arrowsmith CH, Vedadi M, Brown PJ, Nara H and Barsyte-Lovejoy D. Author Correction: Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response. Nat Commun. 2020, 11(1): 2683. PMID: 32457299.
  • Fritz JL, Collins O, Saxena P, Buensuceso A, Ramos Valdes Y, Francis KE, Brown KR, Larsen B, Colwill K, Gingras AC, Rottapel R and Shepherd TG. A novel role for NUAK1 in promoting ovarian cancer metastasis through regulation of fibronectin production in spheroids. Cancers (Basel). 2020. PMID: 32429240.
  • Szewczyk MM, Ishikawa Y, Organ S, Sakai N, Li F, Halabelian L, Ackloo S, Couzens AL, Eram M, Dilworth D, Fukushi H, Harding R, Dela Seña CC, Sugo T, Hayashi K, McLeod D, Zepeda C, Aman A, Sánchez-Osuna M, Bonneil E, Takagi S, Al-Awar R, Tyers M, Richard S, Takizawa M, Gingras AC, Arrowsmith CH, Vedadi M, Brown PJ, Nara H and Barsyte-Lovejoy D. Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response. Nat Commun. 2020, 11(1): 2396. PMID: 32409666.
  • Müller PM, Rademacher J, Bagshaw RD, Wortmann C, Barth C, van Unen J, Alp KM, Giudice G, Eccles RL, Heinrich LE, Pascual-Vargas P, Sanchez-Castro M, Brandenburg L, Mbamalu G, Tucholska M, Spatt L, Czajkowski MT, Welke RW, Zhang S, Nguyen V, Rrustemi T, Trnka P, Freitag K, Larsen B, Popp O, Mertins P, Gingras AC, Roth FP, Colwill K, Bakal C, Pertz O, Pawson T, Petsalaki E and Rocks O. Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions. Nat Cell Biol. 2020, 22(4): 498-511. PMID: 32203420.
  • Gingras AC, Carr SA and Burlingame AL. Virtual Issue: Technological Innovations. Mol Cell Proteomics. 2020, 19(4): 572-573. PMID: 32184224.
  • Burlingame AL, Carr S and Gingras AC. Compliance Checklists No Longer Required at Initial Manuscript Submission. Mol Cell Proteomics. 2020, 19(4): 571. PMID: 32179581.
  • Loganathan SK, Schleicher K, Malik A, Quevedo R, Langille E, Teng K, Oh RH, Rathod B, Tsai R, Samavarchi-Tehrani P, Pugh TJ, Gingras AC and Schramek D. Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling. Science. 2020, 367(6483): 1264-1269. PMID: 32165588.
  • Samavarchi-Tehrani P, Samson R and Gingras AC. Proximity Dependent Biotinylation: Key Enzymes and Adaptation to Proteomics Approaches. Mol Cell Proteomics. 2020, 19(5): 757-773. PMID: 32127388.
  • Bagci H, Sriskandarajah N, Robert A, Boulais J, Elkholi IE, Tran V, Lin ZY, Thibault MP, Dubé N, Faubert D, Hipfner DR, Gingras AC and Côté JF. Author Correction: Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms. Nat Cell Biol. 2020, 22(3): 353. PMID: 32042180.
  • Gonatopoulos-Pournatzis T, Niibori R, Salter EW, Weatheritt RJ, Tsang B, Farhangmehr S, Liang X, Braunschweig U, Roth J, Zhang S, Henderson T, Sharma E, Quesnel-Vallières M, Permanyer J, Maier S, Georgiou J, Irimia M, Sonenberg N, Forman-Kay JD, Gingras AC, Collingridge GL, Woodin MA, Cordes SP and Blencowe BJ. Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions. Mol Cell. 2020, 77(6): 1176-1192.e16. PMID: 31999954.
  • Bian Y, Zheng R, Bayer FP, Wong C, Chang YC, Meng C, Zolg DP, Reinecke M, Zecha J, Wiechmann S, Heinzlmeir S, Scherr J, Hemmer B, Baynham M, Gingras AC, Boychenko O and Kuster B. Robust, reproducible and quantitative analysis of thousands of proteomes by micro-flow LC-MS/MS. Nat Commun. 2020, 11(1): 157. PMID: 31919466.
  • Bagci H, Sriskandarajah N, Robert A, Boulais J, Elkholi IE, Tran V, Lin ZY, Thibault MP, Dubé N, Faubert D, Hipfner DR, Gingras AC and Côté JF. Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms. Nat Cell Biol. 2020, 22(1): 120-134. PMID: 31871319.
  • Gingras AC. Connecting proteins: shareable tools for reproducible interaction mapping. Biochem Cell Biol. 2020, 98(3): 309-313. PMID: 31689129.
  • Méant A, Gao B, Lavoie G, Nourreddine S, Jung F, Aubert L, Tcherkezian J, Gingras AC and Roux PP. Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion. Mol Cell Proteomics. 2020, 19(1): 50-64. PMID: 31678930.
  • O'Connor CM, Leonard D, Wiredja D, Avelar RA, Wang Z, Schlatzer D, Bryson B, Tokala E, Taylor SE, Upadhyay A, Sangodkar J, Gingras AC, Westermarck J, Xu W, DiFeo A, Brautigan DL, Haider S, Jackson M and Narla G. Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors. Oncogene. 2020, 39(3): 703-717. PMID: 31541192.

2019

  • Youn JY, Dyakov BJA, Zhang J, Knight JDR, Vernon RM, Forman-Kay JD and Gingras AC. Properties of Stress Granule and P-Body Proteomes. Mol Cell. 2019, 76(2): 286-294. PMID: 31626750.
  • Anikeeva P, Boyden E, Brangwynne C, Cissé II, Fiehn O, Fromme P, Gingras AC, Greene CS, Heard E, Hell SW, Hillman E, Jensen GJ, Karchin R, Kiessling LL, Kleinstiver BP, Knight R, Kukura P, Lancaster MA, Loman N, Looger L, Lundberg E, Luo Q, Miyawaki A, Myers EW Jr, Nolan GP, Picotti P, Reik W, Sauer M, Shalek AK, Shendure J, Slavov N, Tanay A, Troyanskaya O, van Valen D, Wang HW, Yi C, Yin P, Zernicka-Goetz M and Zhuang X. Voices in methods development. Nat Methods. 2019, 16(10): 945-951. PMID: 31562479.
  • Lahaie S, Morales D, Bagci H, Hamoud N, Castonguay CE, Kazan JM, Desrochers G, Klar A, Gingras AC, Pause A, Côté JF and Kania A. The endosomal sorting adaptor HD-PTP is required for ephrin-B:EphB signalling in cellular collapse and spinal motor axon guidance. Sci Rep. 2019, 9(1): 11945. PMID: 31420572.
  • O'Meara TR, O'Meara MJ, Polvi EJ, Pourhaghighi MR, Liston SD, Lin ZY, Veri AO, Emili A, Gingras AC and Cowen LE. Global proteomic analyses define an environmentally contingent Hsp90 interactome and reveal chaperone-dependent regulation of stress granule proteins and the R2TP complex in a fungal pathogen. PLoS Biol. 2019, 17(7): e3000358. PMID: 31283755.
  • Knight JDR, Samavarchi-Tehrani P, Tyers M and Gingras AC. Gene Information eXtension (GIX): effortless retrieval of gene product information on any website. Nat Methods. 2019, 16(8): 665-666. PMID: 31217594.
  • Ceccarelli DF, Ivantsiv S, Mullin AA, Coyaud E, Manczyk N, Maisonneuve P, Kurinov I, Zhao L, Go C, Gingras AC, Raught B, Cordes S and Sicheri F. FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane. Structure. 2019, 27(6): 1000-1012.e6. PMID: 31056421.
  • Chapman EM, Lant B, Ohashi Y, Yu B, Schertzberg M, Go C, Dogra D, Koskimäki J, Girard R, Li Y, Fraser AG, Awad IA, Abdelilah-Seyfried S, Gingras AC and Derry WB. A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis. Nat Commun. 2019, 10(1): 1791. PMID: 30996251.
  • Torres-Méndez A, Bonnal S, Marquez Y, Roth J, Iglesias M, Permanyer J, Almudí I, O'Hanlon D, Guitart T, Soller M, Gingras AC, Gebauer F, Rentzsch F, Blencowe BJ, Valcárcel J and Irimia M. A novel protein domain in an ancestral splicing factor drove the evolution of neural microexons. Nat Ecol Evol. 2019, 3(4): 691-701. PMID: 30833759.
  • Herbert K, Binet R, Lambert JP, Louphrasitthiphol P, Kalkavan H, Sesma-Sanz L, Robles-Espinoza CD, Sarkar S, Suer E, Andrews S, Chauhan J, Roberts ND, Middleton MR, Gingras AC, Masson JY, Larue L, Falletta P and Goding CR. BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma. Genes Dev. 2019, 33(5-6): 310-332. PMID: 30804224.
  • Ashraf K, Nabeel-Shah S, Garg J, Saettone A, Derynck J, Gingras AC, Lambert JP, Pearlman RE and Fillingham J. Proteomic Analysis of Histones H2A/H2B and Variant Hv1 in Tetrahymena thermophila Reveals an Ancient Network of Chaperones. Mol Biol Evol. 2019, 36(5): 1037-1055. PMID: 30796450.
  • Polvi EJ, Veri AO, Liu Z, Hossain S, Hyde S, Kim SH, Tebbji F, Sellam A, Todd RT, Xie JL, Lin ZY, Wong CJ, Shapiro RS, Whiteway M, Robbins N, Gingras AC, Selmecki A and Cowen LE. Functional divergence of a global regulatory complex governing fungal filamentation. PLoS Genet. 2019, 15(1): e1007901. PMID: 30615616.
  • Lambert JP, Picaud S, Fujisawa T, Hou H, Savitsky P, Uusküla-Reimand L, Gupta GD, Abdouni H, Lin ZY, Tucholska M, Knight JDR, Gonzalez-Badillo B, St-Denis N, Newman JA, Stucki M, Pelletier L, Bandeira N, Wilson MD, Filippakopoulos P and Gingras AC. Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains. Mol Cell. 2019, 73(3): 621-638.e17. PMID: 30554943.
  • Gingras AC, Abe KT and Raught B. Getting to know the neighborhood: using proximity-dependent biotinylation to characterize protein complexes and map organelles. Curr Opin Chem Biol. 2019, 48: 44-54. PMID: 30458335.

2018

  • Gonatopoulos-Pournatzis T, Wu M, Braunschweig U, Roth J, Han H, Best AJ, Raj B, Aregger M, O'Hanlon D, Ellis JD, Calarco JA, Moffat J, Gingras AC and Blencowe BJ. Genome-wide CRISPR-Cas9 Interrogation of Splicing Networks Reveals a Mechanism for Recognition of Autism-Misregulated Neuronal Microexons. Mol Cell. 2018, 72(3): 510-524.e12. PMID: 30388412.
  • Nishimura T, Fakim H, Brandmann T, Youn JY, Gingras AC, Jinek M and Fabian MR. Human MARF1 is an endoribonuclease that interacts with the DCP1:2 decapping complex and degrades target mRNAs. Nucleic Acids Res. 2018, 46(22): 12008-12021. PMID: 30364987.
  • Emmer BT, Hesketh GG, Kotnik E, Tang VT, Lascuna PJ, Xiang J, Gingras AC, Chen XW and Ginsburg D. The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9. Elife. 2018. PMID: 30251625.
  • Gill MK, Christova T, Zhang YY, Gregorieff A, Zhang L, Narimatsu M, Song S, Xiong S, Couzens AL, Tong J, Krieger JR, Moran MF, Zlotta AR, van der Kwast TH, Gingras AC, Sicheri F, Wrana JL and Attisano L. A feed forward loop enforces YAP/TAZ signaling during tumorigenesis. Nat Commun. 2018, 9(1): 3510. PMID: 30158528.
  • Khoriaty R, Hesketh GG, Bernard A, Weyand AC, Mellacheruvu D, Zhu G, Hoenerhoff MJ, McGee B, Everett L, Adams EJ, Zhang B, Saunders TL, Nesvizhskii AI, Klionsky DJ, Shavit JA, Gingras AC and Ginsburg D. Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in vivo. Proc Natl Acad Sci U S A. 2018, 115(33): E7748-E7757. PMID: 30065114.
  • Coyaud E, Ranadheera C, Cheng D, Gonçalves J, Dyakov BJA, Laurent EMN, St-Germain J, Pelletier L, Gingras AC, Brumell JH, Kim PK, Safronetz D and Raught B. Global Interactomics Uncovers Extensive Organellar Targeting by Zika Virus. Mol Cell Proteomics. 2018, 17(11): 2242-2255. PMID: 30037810.
  • Noordermeer SM, Adam S, Setiaputra D, Barazas M, Pettitt SJ, Ling AK, Olivieri M, Álvarez-Quilón A, Moatti N, Zimmermann M, Annunziato S, Krastev DB, Song F, Brandsma I, Frankum J, Brough R, Sherker A, Landry S, Szilard RK, Munro MM, McEwan A, Goullet de Rugy T, Lin ZY, Hart T, Moffat J, Gingras AC, Martin A, van Attikum H, Jonkers J, Lord CJ, Rottenberg S and Durocher D. The shieldin complex mediates 53BP1-dependent DNA repair. Nature. 2018, 560(7716): 117-121. PMID: 30022168.
  • Samavarchi-Tehrani P, Abdouni H, Samson R and Gingras AC. A Versatile Lentiviral Delivery Toolkit for Proximity-dependent Biotinylation in Diverse Cell Types. Mol Cell Proteomics. 2018, 17(11): 2256-2269. PMID: 29991506.
  • Xiong S, Lorenzen K, Couzens AL, Templeton CM, Rajendran D, Mao DYL, Juang YC, Chiovitti D, Kurinov I, Guettler S, Gingras AC and Sicheri F. Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment. Structure. 2018, 26(8): 1101-1115.e6. PMID: 29983373.
  • Burlingame A, Carr S and Gingras AC. Gaining an Easy Visual Grasp on MCP Content. Mol Cell Proteomics. 2018, 17(7): 1259-1260. PMID: 29967216.
  • Khan M, Youn JY, Gingras AC, Subramaniam R and Desveaux D. In planta proximity dependent biotin identification (BioID). Sci Rep. 2018, 8(1): 9212. PMID: 29907827.
  • Hunter MR, Hesketh GG, Benedyk TH, Gingras AC and Graham SC. Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B. J Mol Biol. 2018, 430(14): 2153-2163. PMID: 29778605.
  • Knight JF, Sung VYC, Kuzmin E, Couzens AL, de Verteuil DA, Ratcliffe CDH, Coelho PP, Johnson RM, Samavarchi-Tehrani P, Gruosso T, Smith HW, Lee W, Saleh SM, Zuo D, Zhao H, Guiot MC, Davis RR, Gregg JP, Moraes C, Gingras AC and Park M. KIBRA (WWC1) Is a Metastasis Suppressor Gene Affected by Chromosome 5q Loss in Triple-Negative Breast Cancer. Cell Rep. 2018, 22(12): 3191-3205. PMID: 29562176.
  • Saettone A, Garg J, Lambert JP, Nabeel-Shah S, Ponce M, Burtch A, Thuppu Mudalige C, Gingras AC, Pearlman RE and Fillingham J. The bromodomain-containing protein Ibd1 links multiple chromatin-related protein complexes to highly expressed genes in Tetrahymena thermophila. Epigenetics Chromatin. 2018, 11(1): 10. PMID: 29523178.
  • Brandmann T, Fakim H, Padamsi Z, Youn JY, Gingras AC, Fabian MR and Jinek M. Molecular architecture of LSM14 interactions involved in the assembly of mRNA silencing complexes. EMBO J. 2018. PMID: 29510985.
  • Jafarnejad SM, Chapat C, Matta-Camacho E, Gelbart IA, Hesketh GG, Arguello M, Garzia A, Kim SH, Attig J, Shapiro M, Morita M, Khoutorsky A, Alain T, Gkogkas CG, Stern-Ginossar N, Tuschl T, Gingras AC, Duchaine TF and Sonenberg N. Translational control of ERK signaling through miRNA/4EHP-directed silencing. Elife. 2018. PMID: 29412140.
  • Youn JY, Dunham WH, Hong SJ, Knight JDR, Bashkurov M, Chen GI, Bagci H, Rathod B, MacLeod G, Eng SWM, Angers S, Morris Q, Fabian M, Côté JF and Gingras AC. High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. Mol Cell. 2018, 69(3): 517-532.e11. PMID: 29395067.

2017

  • Sandí MJ, Marshall CB, Balan M, Coyaud É, Zhou M, Monson DM, Ishiyama N, Chandrakumar AA, La Rose J, Couzens AL, Gingras AC, Raught B, Xu W, Ikura M, Morrison DK and Rottapel R. MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity. Sci Signal. 2017. PMID: 29089450.
  • Xie JL, Bohovych I, Wong EOY, Lambert JP, Gingras AC, Khalimonchuk O, Cowen LE and Leach MD. Ydj1 governs fungal morphogenesis and stress response, and facilitates mitochondrial protein import via Mas1 and Mas2. Microb Cell. 2017, 4(10): 342-361. PMID: 29082232.
  • Smith MJ, Ottoni E, Ishiyama N, Goudreault M, Haman A, Meyer C, Tucholska M, Gasmi-Seabrook G, Menezes S, Laister RC, Minden MD, Marschalek R, Gingras AC, Hoang T and Ikura M. Evolution of AF6-RAS association and its implications in mixed-lineage leukemia. Nat Commun. 2017, 8(1): 1099. PMID: 29062045.
  • Meier JC, Tallant C, Fedorov O, Witwicka H, Hwang SY, van Stiphout RG, Lambert JP, Rogers C, Yapp C, Gerstenberger BS, Fedele V, Savitsky P, Heidenreich D, Daniels DL, Owen DR, Fish PV, Igoe NM, Bayle ED, Haendler B, Oppermann UCT, Buffa F, Brennan PE, Müller S, Gingras AC, Odgren PR, Birnbaum MJ and Knapp S. Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation. ACS Chem Biol. 2017, 12(10): 2619-2630. PMID: 28849908.
  • Collins BC, Hunter CL, Liu Y, Schilling B, Rosenberger G, Bader SL, Chan DW, Gibson BW, Gingras AC, Held JM, Hirayama-Kurogi M, Hou G, Krisp C, Larsen B, Lin L, Liu S, Molloy MP, Moritz RL, Ohtsuki S, Schlapbach R, Selevsek N, Thomas SN, Tzeng SC, Zhang H and Aebersold R. Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry. Nat Commun. 2017, 8(1): 291. PMID: 28827567.
  • Gu B, Lambert JP, Cockburn K, Gingras AC and Rossant J. AIRE is a critical spindle-associated protein in embryonic stem cells. Elife. 2017. PMID: 28742026.
  • Johnston WL, Krizus A, Ramani AK, Dunham W, Youn JY, Fraser AG, Gingras AC and Dennis JW. C. elegans SUP-46, an HNRNPM family RNA-binding protein that prevents paternally-mediated epigenetic sterility. BMC Biol. 2017, 15(1): 61. PMID: 28716093.
  • Gueroussov S, Weatheritt RJ, O'Hanlon D, Lin ZY, Narula A, Gingras AC and Blencowe BJ. Regulatory Expansion in Mammals of Multivalent hnRNP Assemblies that Globally Control Alternative Splicing. Cell. 2017, 170(2): 324-339.e23. PMID: 28709000.
  • Knight JDR, Choi H, Gupta GD, Pelletier L, Raught B, Nesvizhskii AI and Gingras AC. ProHits-viz: a suite of web tools for visualizing interaction proteomics data. Nat Methods. 2017, 14(7): 645-646. PMID: 28661499.
  • Mojarad BA, Gupta GD, Hasegan M, Goudiam O, Basto R, Gingras AC and Pelletier L. CEP19 cooperates with FOP and CEP350 to drive early steps in the ciliogenesis programme. Open Biol. 2017. PMID: 28659385.
  • Courcelles M, Coulombe-Huntington J, Cossette É, Gingras AC, Thibault P and Tyers M. CLMSVault: A Software Suite for Protein Cross-Linking Mass-Spectrometry Data Analysis and Visualization. J Proteome Res. 2017, 16(7): 2645-2652. PMID: 28537071.
  • Chapat C, Jafarnejad SM, Matta-Camacho E, Hesketh GG, Gelbart IA, Attig J, Gkogkas CG, Alain T, Stern-Ginossar N, Fabian MR, Gingras AC, Duchaine TF and Sonenberg N. Cap-binding protein 4EHP effects translation silencing by microRNAs. Proc Natl Acad Sci U S A. 2017, 114(21): 5425-5430. PMID: 28487484.
  • Couzens AL, Xiong S, Knight JDR, Mao DY, Guettler S, Picaud S, Kurinov I, Filippakopoulos P, Sicheri F and Gingras AC. MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway. Mol Cell Proteomics. 2017, 16(6): 1098-1110. PMID: 28373298.
  • Xiong S, Couzens AL, Kean MJ, Mao DY, Guettler S, Kurinov I, Gingras AC and Sicheri F. Regulation of Protein Interactions by Mps One Binder (MOB1) Phosphorylation. Mol Cell Proteomics. 2017, 16(6): 1111-1125. PMID: 28373297.
  • Pal S, Lant B, Yu B, Tian R, Tong J, Krieger JR, Moran MF, Gingras AC and Derry WB. CCM-3 Promotes C. elegans Germline Development by Regulating Vesicle Trafficking Cytokinesis and Polarity. Curr Biol. 2017, 27(6): 868-876. PMID: 28285997.
  • Hesketh GG, Youn JY, Samavarchi-Tehrani P, Raught B and Gingras AC. Parallel Exploration of Interaction Space by BioID and Affinity Purification Coupled to Mass Spectrometry. Methods Mol Biol. 2017, 1550: 115-136. PMID: 28188527.
  • Yao Z, Darowski K, St-Denis N, Wong V, Offensperger F, Villedieu A, Amin S, Malty R, Aoki H, Guo H, Xu Y, Iorio C, Kotlyar M, Emili A, Jurisica I, Neel BG, Babu M, Gingras AC and Stagljar I. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Mol Cell. 2017, 65(2): 347-360. PMID: 28065597.
  • Antonicka H, Choquet K, Lin ZY, Gingras AC, Kleinman CL and Shoubridge EA. A pseudouridine synthase module is essential for mitochondrial protein synthesis and cell viability. EMBO Rep. 2017, 18(1): 28-38. PMID: 27974379.
  • Uhrig RG, Labandera AM, Tang LY, Sieben NA, Goudreault M, Yeung E, Gingras AC, Samuel MA and Moorhead GB. Activation of Mitochondrial Protein Phosphatase SLP2 by MIA40 Regulates Seed Germination. Plant Physiol. 2017, 173(2): 956-969. PMID: 27923987.
  • Billon P, Li J, Lambert JP, Chen Y, Tremblay V, Brunzelle JS, Gingras AC, Verreault A, Sugiyama T, Couture JF and Côté J. Acetylation of PCNA Sliding Surface by Eco1 Promotes Genome Stability through Homologous Recombination. Mol Cell. 2017, 65(1): 78-90. PMID: 27916662.
  • Wan LC, Maisonneuve P, Szilard RK, Lambert JP, Ng TF, Manczyk N, Huang H, Laister R, Caudy AA, Gingras AC, Durocher D and Sicheri F. Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7. Nucleic Acids Res. 2017, 45(2): 805-817. PMID: 27903914.
  • Kazazian K, Go C, Wu H, Brashavitskaya O, Xu R, Dennis JW, Gingras AC and Swallow CJ. Plk4 Promotes Cancer Invasion and Metastasis through Arp2/3 Complex Regulation of the Actin Cytoskeleton. Cancer Res. 2017, 77(2): 434-447. PMID: 27872092.

2016

  • Savitsky P, Krojer T, Fujisawa T, Lambert JP, Picaud S, Wang CY, Shanle EK, Krajewski K, Friedrichsen H, Kanapin A, Goding C, Schapira M, Samsonova A, Strahl BD, Gingras AC and Filippakopoulos P. Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin. Cell Rep. 2016, 17(10): 2724-2737. PMID: 27926874.
  • St-Denis N, Gupta GD, Lin ZY, Gonzalez-Badillo B, Veri AO, Knight JDR, Rajendran D, Couzens AL, Currie KW, Tkach JM, Cheung SWT, Pelletier L and Gingras AC. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. Cell Rep. 2016, 17(9): 2488-2501. PMID: 27880917.
  • van Leeuwen J, Pons C, Mellor JC, Yamaguchi TN, Friesen H, Koschwanez J, Ušaj MM, Pechlaner M, Takar M, Ušaj M, VanderSluis B, Andrusiak K, Bansal P, Baryshnikova A, Boone CE, Cao J, Cote A, Gebbia M, Horecka G, Horecka I, Kuzmin E, Legro N, Liang W, van Lieshout N, McNee M, San Luis BJ, Shaeri F, Shuteriqi E, Sun S, Yang L, Youn JY, Yuen M, Costanzo M, Gingras AC, Aloy P, Oostenbrink C, Murray A, Graham TR, Myers CL, Andrews BJ, Roth FP and Boone C. Exploring genetic suppression interactions on a global scale. Science. 2016. PMID: 27811238.
  • Picaud S, Leonards K, Lambert JP, Dovey O, Wells C, Fedorov O, Monteiro O, Fujisawa T, Wang CY, Lingard H, Tallant C, Nikbin N, Guetzoyan L, Ingham R, Ley SV, Brennan P, Muller S, Samsonova A, Gingras AC, Schwaller J, Vassiliou G, Knapp S and Filippakopoulos P. Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia. Sci Adv. 2016, 2(10): e1600760. PMID: 27757418.
  • Costanzo M, VanderSluis B, Koch EN, Baryshnikova A, Pons C, Tan G, Wang W, Usaj M, Hanchard J, Lee SD, Pelechano V, Styles EB, Billmann M, van Leeuwen J, van Dyk N, Lin ZY, Kuzmin E, Nelson J, Piotrowski JS, Srikumar T, Bahr S, Chen Y, Deshpande R, Kurat CF, Li SC, Li Z, Usaj MM, Okada H, Pascoe N, San Luis BJ, Sharifpoor S, Shuteriqi E, Simpkins SW, Snider J, Suresh HG, Tan Y, Zhu H, Malod-Dognin N, Janjic V, Przulj N, Troyanskaya OG, Stagljar I, Xia T, Ohya Y, Gingras AC, Raught B, Boutros M, Steinmetz LM, Moore CL, Rosebrock AP, Caudy AA, Myers CL, Andrews B and Boone C. A global genetic interaction network maps a wiring diagram of cellular function. Science. 2016. PMID: 27708008.
  • Uusküla-Reimand L, Hou H, Samavarchi-Tehrani P, Rudan MV, Liang M, Medina-Rivera A, Mohammed H, Schmidt D, Schwalie P, Young EJ, Reimand J, Hadjur S, Gingras AC and Wilson MD. Topoisomerase II beta interacts with cohesin and CTCF at topological domain borders. Genome Biol. 2016, 17(1): 182. PMID: 27582050.
  • Shekhar-Guturja T, Gunaherath GM, Wijeratne EM, Lambert JP, Averette AF, Lee SC, Kim T, Bahn YS, Tripodi F, Ammar R, Döhl K, Niewola-Staszkowska K, Schmitt L, Loewith RJ, Roth FP, Sanglard D, Andes D, Nislow C, Coccetti P, Gingras AC, Heitman J, Gunatilaka AA and Cowen LE. Dual action antifungal small molecule modulates multidrug efflux and TOR signaling. Nat Chem Biol. 2016, 12(10): 867-75. PMID: 27571477.
  • Campbell CI, Samavarchi-Tehrani P, Barrios-Rodiles M, Datti A, Gingras AC and Wrana JL. The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin. J Cell Sci. 2016, 129(18): 3396-411. PMID: 27521426.
  • Gingras AC and Wong CJ. Proteomics approaches to decipher new signaling pathways. Curr Opin Struct Biol. 2016, 41: 128-134. PMID: 27449970.
  • Janer A, Prudent J, Paupe V, Fahiminiya S, Majewski J, Sgarioto N, Des Rosiers C, Forest A, Lin ZY, Gingras AC, Mitchell G, McBride HM and Shoubridge EA. SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome. EMBO Mol Med. 2016, 8(9): 1019-38. PMID: 27390132.
  • Pupavac M, Watkins D, Petrella F, Fahiminiya S, Janer A, Cheung W, Gingras AC, Pastinen T, Muenzer J, Majewski J, Shoubridge EA and Rosenblatt DS. Inborn Error of Cobalamin Metabolism Associated with the Intracellular Accumulation of Transcobalamin-Bound Cobalamin and Mutations in ZNF143, Which Codes for a Transcriptional Activator. Hum Mutat. 2016, 37(9): 976-82. PMID: 27349184.
  • Jacquet K, Fradet-Turcotte A, Avvakumov N, Lambert JP, Roques C, Pandita RK, Paquet E, Herst P, Gingras AC, Pandita TK, Legube G, Doyon Y, Durocher D and Côté J. The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation. Mol Cell. 2016, 62(3): 409-421. PMID: 27153538.
  • Liu G, Knight JD, Zhang JP, Tsou CC, Wang J, Lambert JP, Larsen B, Tyers M, Raught B, Bandeira N, Nesvizhskii AI, Choi H and Gingras AC. Data Independent Acquisition analysis in ProHits 4.0. J Proteomics. 2016, 149: 64-68. PMID: 27132685.
  • Teo G, Koh H, Fermin D, Lambert JP, Knight JD, Gingras AC and Choi H. SAINTq: Scoring protein-protein interactions in affinity purification - mass spectrometry experiments with fragment or peptide intensity data. Proteomics. 2016, 16(15-16): 2238-45. PMID: 27119218.
  • Chattopadhyay D, Swingle MR, Salter EA, Wood E, D'Arcy B, Zivanov C, Abney K, Musiyenko A, Rusin SF, Kettenbach A, Yet L, Schroeder CE, Golden JE, Dunham WH, Gingras AC, Banerjee S, Forbes D, Wierzbicki A and Honkanen RE. Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C. Biochem Pharmacol. 2016, 109: 14-26. PMID: 27002182.
  • de Kreuk BJ, Gingras AR, Knight JD, Liu JJ, Gingras AC and Ginsberg MH. Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity. Elife. 2016, 5: e11394. PMID: 26780829.
  • Tkáč J, Xu G, Adhikary H, Young JTF, Gallo D, Escribano-Díaz C, Krietsch J, Orthwein A, Munro M, Sol W, Al-Hakim A, Lin ZY, Jonkers J, Borst P, Brown GW, Gingras AC, Rottenberg S, Masson JY and Durocher D. HELB Is a Feedback Inhibitor of DNA End Resection. Mol Cell. 2016, 61(3): 405-418. PMID: 26774285.
  • Feng Y, Vlassis A, Roques C, Lalonde ME, González-Aguilera C, Lambert JP, Lee SB, Zhao X, Alabert C, Johansen JV, Paquet E, Yang XJ, Gingras AC, Côté J and Groth A. BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation. EMBO J. 2016, 35(2): 176-92. PMID: 26620551.

2015

  • Gupta GD, Coyaud É, Gonçalves J, Mojarad BA, Liu Y, Wu Q, Gheiratmand L, Comartin D, Tkach JM, Cheung SW, Bashkurov M, Hasegan M, Knight JD, Lin ZY, Schueler M, Hildebrandt F, Moffat J, Gingras AC, Raught B and Pelletier L. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. Cell. 2015, 163(6): 1484-99. PMID: 26638075.
  • Wang J, Tucholska M, Knight JD, Lambert JP, Tate S, Larsen B, Gingras AC and Bandeira N. MSPLIT-DIA: sensitive peptide identification for data-independent acquisition. Nat Methods. 2015, 12(12): 1106-8. PMID: 26550773.
  • Teo G, Kim S, Tsou CC, Collins B, Gingras AC, Nesvizhskii AI and Choi H. mapDIA: Preprocessing and statistical analysis of quantitative proteomics data from data independent acquisition mass spectrometry. J Proteomics. 2015, 129: 108-120. PMID: 26381204.
  • Gueroussov S, Gonatopoulos-Pournatzis T, Irimia M, Raj B, Lin ZY, Gingras AC and Blencowe BJ. An alternative splicing event amplifies evolutionary differences between vertebrates. Science. 2015, 349(6250): 868-73. PMID: 26293963.
  • Scifo E, Szwajda A, Soliymani R, Pezzini F, Bianchi M, Dapkunas A, Dębski J, Uusi-Rauva K, Dadlez M, Gingras AC, Tyynelä J, Simonati A, Jalanko A, Baumann MH and Lalowski M. Quantitative analysis of PPT1 interactome in human neuroblastoma cells. Data Brief. 2015, 4: 207-16. PMID: 26217791.
  • Marcon E, Jain H, Bhattacharya A, Guo H, Phanse S, Pu S, Byram G, Collins BC, Dowdell E, Fenner M, Guo X, Hutchinson A, Kennedy JJ, Krastins B, Larsen B, Lin ZY, Lopez MF, Loppnau P, Miersch S, Nguyen T, Olsen JB, Paduch M, Ravichandran M, Seitova A, Vadali G, Vogelsang MS, Whiteaker JR, Zhong G, Zhong N, Zhao L, Aebersold R, Arrowsmith CH, Emili A, Frappier L, Gingras AC, Gstaiger M, Paulovich AG, Koide S, Kossiakoff AA, Sidhu SS, Wodak SJ, Gräslund S, Greenblatt JF and Edwards AM. Assessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation. Nat Methods. 2015, 12(8): 725-31. PMID: 26121405.
  • Mui MZ, Zhou Y, Blanchette P, Chughtai N, Knight JF, Gruosso T, Papadakis AI, Huang S, Park M, Gingras AC and Branton PE. The Human Adenovirus Type 5 E4orf4 Protein Targets Two Phosphatase Regulators of the Hippo Signaling Pathway. J Virol. 2015, 89(17): 8855-70. PMID: 26085163.
  • Nishimura T, Padamsi Z, Fakim H, Milette S, Dunham WH, Gingras AC and Fabian MR. The eIF4E-Binding Protein 4E-T Is a Component of the mRNA Decay Machinery that Bridges the 5' and 3' Termini of Target mRNAs. Cell Rep. 2015, 11(9): 1425-36. PMID: 26027925.
  • Coyaud E, Mis M, Laurent EM, Dunham WH, Couzens AL, Robitaille M, Gingras AC, Angers S and Raught B. BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates. Mol Cell Proteomics. 2015, 14(7): 1781-95. PMID: 25900982.
  • Thibault P and Gingras AC. Proteome dynamics in health and disease. Foreword. J Proteomics. 2015, 118: 1. PMID: 25866385.
  • Scifo E, Szwajda A, Soliymani R, Pezzini F, Bianchi M, Dapkunas A, Dębski J, Uusi-Rauva K, Dadlez M, Gingras AC, Tyynelä J, Simonati A, Jalanko A, Baumann MH and Lalowski M. Proteomic analysis of the palmitoyl protein thioesterase 1 interactome in SH-SY5Y human neuroblastoma cells. J Proteomics. 2015, 123: 42-53. PMID: 25865307.
  • Tian R, Wang H, Gish GD, Petsalaki E, Pasculescu A, Shi Y, Mollenauer M, Bagshaw RD, Yosef N, Hunter T, Gingras AC, Weiss A and Pawson T. Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor. Proc Natl Acad Sci U S A. 2015, 112(13): E1594-603. PMID: 25829543.
  • Lant B, Yu B, Goudreault M, Holmyard D, Knight JD, Xu P, Zhao L, Chin K, Wallace E, Zhen M, Gingras AC and Derry WB. CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling. Nat Commun. 2015, 6: 6449. PMID: 25743393.
  • St-Denis N, Gupta GD, Lin ZY, Gonzalez-Badillo B, Pelletier L and Gingras AC. Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission. Mol Cell Proteomics. 2015, 14(4): 946-60. PMID: 25659891.
  • Tsou CC, Avtonomov D, Larsen B, Tucholska M, Choi H, Gingras AC and Nesvizhskii AI. DIA-Umpire: comprehensive computational framework for data-independent acquisition proteomics. Nat Methods. 2015, 12(3): 258-64, 7 p following 264. PMID: 25599550.
  • St-Denis N, Gabriel M, Turowec JP, Gloor GB, Li SS, Gingras AC and Litchfield DW. Systematic investigation of hierarchical phosphorylation by protein kinase CK2. J Proteomics. 2015, 118: 49-62. PMID: 25449829.
  • Knight JD, Liu G, Zhang JP, Pasculescu A, Choi H and Gingras AC. A web-tool for visualizing quantitative protein-protein interaction data. Proteomics. 2015, 15(8): 1432-6. PMID: 25422071.
  • Lambert JP, Tucholska M, Go C, Knight JD and Gingras AC. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. J Proteomics. 2015, 118: 81-94. PMID: 25281560.

2014

  • Liu YC, Couzens AL, Deshwar AR, B McBroom-Cerajewski LD, Zhang X, Puviindran V, Scott IC, Gingras AC, Hui CC and Angers S. The PPFIA1-PP2A protein complex promotes trafficking of Kif7 to the ciliary tip and Hedgehog signaling. Sci Signal. 2014, 7(355): ra117. PMID: 25492966.
  • Gray EJ, Petsalaki E, James DA, Bagshaw RD, Stacey MM, Rocks O, Gingras AC and Pawson T. Src homology 2 domain containing protein 5 (SH2D5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP. J Biol Chem. 2014, 289(51): 35397-408. PMID: 25331951.
  • Kurat CF, Lambert JP, Petschnigg J, Friesen H, Pawson T, Rosebrock A, Gingras AC, Fillingham J and Andrews B. Cell cycle-regulated oscillator coordinates core histone gene transcription through histone acetylation. Proc Natl Acad Sci U S A. 2014, 111(39): 14124-9. PMID: 25228766.
  • Raj B, Irimia M, Braunschweig U, Sterne-Weiler T, O'Hanlon D, Lin ZY, Chen GI, Easton LE, Ule J, Gingras AC, Eyras E and Blencowe BJ. A global regulatory mechanism for activating an exon network required for neurogenesis. Mol Cell. 2014, 56(1): 90-103. PMID: 25219497.
  • Meiri D, Marshall CB, Mokady D, LaRose J, Mullin M, Gingras AC, Ikura M and Rottapel R. Mechanistic insight into GPCR-mediated activation of the microtubule-associated RhoA exchange factor GEF-H1. Nat Commun. 2014, 5: 4857. PMID: 25209408.
  • Barsyte-Lovejoy D, Li F, Oudhoff MJ, Tatlock JH, Dong A, Zeng H, Wu H, Freeman SA, Schapira M, Senisterra GA, Kuznetsova E, Marcellus R, Allali-Hassani A, Kennedy S, Lambert JP, Couzens AL, Aman A, Gingras AC, Al-Awar R, Fish PV, Gerstenberger BS, Roberts L, Benn CL, Grimley RL, Braam MJ, Rossi FM, Sudol M, Brown PJ, Bunnage ME, Owen DR, Zaph C, Vedadi M and Arrowsmith CH. (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proc Natl Acad Sci U S A. 2014, 111(35): 12853-8. PMID: 25136132.
  • Philpott M, Rogers CM, Yapp C, Wells C, Lambert JP, Strain-Damerell C, Burgess-Brown NA, Gingras AC, Knapp S and Müller S. Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching. Epigenetics Chromatin. 2014, 7: 14. PMID: 25097667.
  • Taipale M, Tucker G, Peng J, Krykbaeva I, Lin ZY, Larsen B, Choi H, Berger B, Gingras AC and Lindquist S. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. Cell. 2014, 158(2): 434-448. PMID: 25036637.
  • Jović M, Kean MJ, Dubankova A, Boura E, Gingras AC, Brill JA and Balla T. Endosomal sorting of VAMP3 is regulated by PI4K2A. J Cell Sci. 2014, 127(Pt 17): 3745-56. PMID: 25002402.
  • O'Neill DJ, Williamson SC, Alkharaif D, Monteiro IC, Goudreault M, Gaughan L, Robson CN, Gingras AC and Binda O. SETD6 controls the expression of estrogen-responsive genes and proliferation of breast carcinoma cells. Epigenetics. 2014, 9(7): 942-50. PMID: 24751716.
  • Rojas M, Gingras AC and Dever TE. Protein phosphatase PP1/GLC7 interaction domain in yeast eIF2γ bypasses targeting subunit requirement for eIF2α dephosphorylation. Proc Natl Acad Sci U S A. 2014, 111(14): E1344-53. PMID: 24706853.
  • Sakamaki J, Fu A, Reeks C, Baird S, Depatie C, Al Azzabi M, Bardeesy N, Gingras AC, Yee SP and Screaton RA. Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation. Nat Cell Biol. 2014, 16(3): 234-44. PMID: 24561619.
  • Cullis J, Meiri D, Sandi MJ, Radulovich N, Kent OA, Medrano M, Mokady D, Normand J, Larose J, Marcotte R, Marshall CB, Ikura M, Ketela T, Moffat J, Neel BG, Gingras AC, Tsao MS and Rottapel R. The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1. Cancer Cell. 2014, 25(2): 181-95. PMID: 24525234.
  • Teo G, Liu G, Zhang J, Nesvizhskii AI, Gingras AC and Choi H. SAINTexpress: improvements and additional features in Significance Analysis of INTeractome software. J Proteomics. 2014, 100: 37-43. PMID: 24513533.
  • Lambert JP, Tucholska M, Pawson T and Gingras AC. Incorporating DNA shearing in standard affinity purification allows simultaneous identification of both soluble and chromatin-bound interaction partners. J Proteomics. 2014, 100: 55-9. PMID: 24412199.

2013

  • Louria-Hayon I, Frelin C, Ruston J, Gish G, Jin J, Kofler MM, Lambert JP, Adissu HA, Milyavsky M, Herrington R, Minden MD, Dick JE, Gingras AC, Iscove NN and Pawson T. Lnk adaptor suppresses radiation resistance and radiation-induced B-cell malignancies by inhibiting IL-11 signaling. Proc Natl Acad Sci U S A. 2013, 110(51): 20599-604. PMID: 24297922.
  • Couzens AL, Knight JD, Kean MJ, Teo G, Weiss A, Dunham WH, Lin ZY, Bagshaw RD, Sicheri F, Pawson T, Wrana JL, Choi H and Gingras AC. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Sci Signal. 2013, 6(302): rs15. PMID: 24255178.
  • Lambert JP, Ivosev G, Couzens AL, Larsen B, Taipale M, Lin ZY, Zhong Q, Lindquist S, Vidal M, Aebersold R, Pawson T, Bonner R, Tate S and Gingras AC. Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition. Nat Methods. 2013, 10(12): 1239-45. PMID: 24162924.
  • Garg J, Lambert JP, Karsou A, Marquez S, Nabeel-Shah S, Bertucci V, Retnasothie DV, Radovani E, Pawson T, Gingras AC, Pearlman RE and Fillingham JS. Conserved Asf1-importin β physical interaction in growth and sexual development in the ciliate Tetrahymena thermophila. J Proteomics. 2013, 94: 311-26. PMID: 24120531.
  • Mellacheruvu D, Wright Z, Couzens AL, Lambert JP, St-Denis NA, Li T, Miteva YV, Hauri S, Sardiu ME, Low TY, Halim VA, Bagshaw RD, Hubner NC, Al-Hakim A, Bouchard A, Faubert D, Fermin D, Dunham WH, Goudreault M, Lin ZY, Badillo BG, Pawson T, Durocher D, Coulombe B, Aebersold R, Superti-Furga G, Colinge J, Heck AJ, Choi H, Gstaiger M, Mohammed S, Cristea IM, Bennett KL, Washburn MP, Raught B, Ewing RM, Gingras AC and Nesvizhskii AI. The CRAPome: a contaminant repository for affinity purification-mass spectrometry data. Nat Methods. 2013, 10(8): 730-6. PMID: 23921808.
  • Fermin D, Walmsley SJ, Gingras AC, Choi H and Nesvizhskii AI. LuciPHOr: algorithm for phosphorylation site localization with false localization rate estimation using modified target-decoy approach. Mol Cell Proteomics. 2013, 12(11): 3409-19. PMID: 23918812.
  • Oudhoff MJ, Freeman SA, Couzens AL, Antignano F, Kuznetsova E, Min PH, Northrop JP, Lehnertz B, Barsyte-Lovejoy D, Vedadi M, Arrowsmith CH, Nishina H, Gold MR, Rossi FM, Gingras AC and Zaph C. Control of the hippo pathway by Set7-dependent methylation of Yap. Dev Cell. 2013, 26(2): 188-94. PMID: 23850191.
  • Zheng Y, Zhang C, Croucher DR, Soliman MA, St-Denis N, Pasculescu A, Taylor L, Tate SA, Hardy WR, Colwill K, Dai AY, Bagshaw R, Dennis JW, Gingras AC, Daly RJ and Pawson T. Temporal regulation of EGF signalling networks by the scaffold protein Shc1. Nature. 2013, 499(7457): 166-71. PMID: 23846654.
  • Rivkin E, Almeida SM, Ceccarelli DF, Juang YC, MacLean TA, Srikumar T, Huang H, Dunham WH, Fukumura R, Xie G, Gondo Y, Raught B, Gingras AC, Sicheri F and Cordes SP. The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis. Nature. 2013, 498(7454): 318-24. PMID: 23708998.
  • Newman RH, Hu J, Rho HS, Xie Z, Woodard C, Neiswinger J, Cooper C, Shirley M, Clark HM, Hu S, Hwang W, Jeong JS, Wu G, Lin J, Gao X, Ni Q, Goel R, Xia S, Ji H, Dalby KN, Birnbaum MJ, Cole PA, Knapp S, Ryazanov AG, Zack DJ, Blackshaw S, Pawson T, Gingras AC, Desiderio S, Pandey A, Turk BE, Zhang J, Zhu H and Qian J. Construction of human activity-based phosphorylation networks. Mol Syst Biol. 2013, 9: 655. PMID: 23549483.
  • Scifo E, Szwajda A, Dębski J, Uusi-Rauva K, Kesti T, Dadlez M, Gingras AC, Tyynelä J, Baumann MH, Jalanko A and Lalowski M. Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. J Proteome Res. 2013, 12(5): 2101-15. PMID: 23464991.
  • Tate S, Larsen B, Bonner R and Gingras AC. Label-free quantitative proteomics trends for protein-protein interactions. J Proteomics. 2013, 81: 91-101. PMID: 23153790.
  • Knight JD, Pawson T and Gingras AC. Profiling the kinome: current capabilities and future challenges. J Proteomics. 2013, 81: 43-55. PMID: 23099349.

2012

  • Oberg EA, Nifoussi SK, Gingras AC and Strack S. Selective proteasomal degradation of the B'β subunit of protein phosphatase 2A by the E3 ubiquitin ligase adaptor Kelch-like 15. J Biol Chem. 2012, 287(52): 43378-89. PMID: 23135275.
  • Mak AB, Nixon AM, Kittanakom S, Stewart JM, Chen GI, Curak J, Gingras AC, Mazitschek R, Neel BG, Stagljar I and Moffat J. Regulation of CD133 by HDAC6 promotes β-catenin signaling to suppress cancer cell differentiation. Cell Rep. 2012, 2(4): 951-63. PMID: 23084749.
  • Ryan O, Shapiro RS, Kurat CF, Mayhew D, Baryshnikova A, Chin B, Lin ZY, Cox MJ, Vizeacoumar F, Cheung D, Bahr S, Tsui K, Tebbji F, Sellam A, Istel F, Schwarzmüller T, Reynolds TB, Kuchler K, Gifford DK, Whiteway M, Giaever G, Nislow C, Costanzo M, Gingras AC, Mitra RD, Andrews B, Fink GR, Cowen LE and Boone C. Global gene deletion analysis exploring yeast filamentous growth. Science. 2012, 337(6100): 1353-6. PMID: 22984072.
  • Liu G, Zhang J, Choi H, Lambert JP, Srikumar T, Larsen B, Nesvizhskii AI, Raught B, Tyers M and Gingras AC. Using ProHits to store, annotate, and analyze affinity purification-mass spectrometry (AP-MS) data. Curr Protoc Bioinformatics. 2012, Chapter 8: Unit8.16. PMID: 22948730.
  • Choi H, Liu G, Mellacheruvu D, Tyers M, Gingras AC and Nesvizhskii AI. Analyzing protein-protein interactions from affinity purification-mass spectrometry data with SAINT. Curr Protoc Bioinformatics. 2012, Chapter 8: Unit8.15. PMID: 22948729.
  • Gomez-Ferreria MA, Bashkurov M, Mullin M, Gingras AC and Pelletier L. CEP192 interacts physically and functionally with the K63-deubiquitinase CYLD to promote mitotic spindle assembly. Cell Cycle. 2012, 11(19): 3555-8. PMID: 22895009.
  • Belozerov VE, Lin ZY, Gingras AC, McDermott JC and Michael Siu KW. High-resolution protein interaction map of the Drosophila melanogaster p38 mitogen-activated protein kinases reveals limited functional redundancy. Mol Cell Biol. 2012, 32(18): 3695-706. PMID: 22801366.
  • van Zuylen WJ, Doyon P, Clément JF, Khan KA, D'Ambrosio LM, Dô F, St-Amant-Verret M, Wissanji T, Emery G, Gingras AC, Meloche S and Servant MJ. Proteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunity. PLoS Pathog. 2012, 8(7): e1002747. PMID: 22792062.
  • Costa B, Kean MJ, Ast V, Knight JD, Mett A, Levy Z, Ceccarelli DF, Badillo BG, Eils R, König R, Gingras AC and Fainzilber M. STK25 protein mediates TrkA and CCM2 protein-dependent death in pediatric tumor cells of neural origin. J Biol Chem. 2012, 287(35): 29285-9. PMID: 22782892.
  • Morita M, Ler LW, Fabian MR, Siddiqui N, Mullin M, Henderson VC, Alain T, Fonseca BD, Karashchuk G, Bennett CF, Kabuta T, Higashi S, Larsson O, Topisirovic I, Smith RJ, Gingras AC and Sonenberg N. A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development. Mol Cell Biol. 2012, 32(17): 3585-93. PMID: 22751931.
  • Braun P and Gingras AC. History of protein-protein interactions: from egg-white to complex networks. Proteomics. 2012, 12(10): 1478-98. PMID: 22711592.
  • Gingras AC and Nesvizhskii A. Protein complexes and interaction networks. Proteomics. 2012, 12(10): 1475-7. PMID: 22711591.
  • Gingras AC and Raught B. Beyond hairballs: The use of quantitative mass spectrometry data to understand protein-protein interactions. FEBS Lett. 2012, 586(17): 2723-31. PMID: 22710165.
  • Kean MJ, Couzens AL and Gingras AC. Mass spectrometry approaches to study mammalian kinase and phosphatase associated proteins. Methods. 2012, 57(4): 400-8. PMID: 22710030.
  • Dunham WH, Mullin M and Gingras AC. Affinity-purification coupled to mass spectrometry: basic principles and strategies. Proteomics. 2012, 12(10): 1576-90. PMID: 22611051.
  • Lambert JP, Pawson T and Gingras AC. Mapping physical interactions within chromatin by proteomic approaches. Proteomics. 2012, 12(10): 1609-22. PMID: 22611019.
  • Gomez-Ferreria MA, Bashkurov M, Helbig AO, Larsen B, Pawson T, Gingras AC and Pelletier L. Novel NEDD1 phosphorylation sites regulate γ-tubulin binding and mitotic spindle assembly. J Cell Sci. 2012, 125(Pt 16): 3745-51. PMID: 22595525.
  • Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Müller S, Pawson T, Gingras AC, Arrowsmith CH and Knapp S. Histone recognition and large-scale structural analysis of the human bromodomain family. Cell. 2012, 149(1): 214-31. PMID: 22464331.
  • Knight JD, Tian R, Lee RE, Wang F, Beauvais A, Zou H, Megeney LA, Gingras AC, Pawson T, Figeys D and Kothary R. A novel whole-cell lysate kinase assay identifies substrates of the p38 MAPK in differentiating myoblasts. Skelet Muscle. 2012, 2: 5. PMID: 22394512.
  • St-Denis N and Gingras AC. Mass spectrometric tools for systematic analysis of protein phosphorylation. Prog Mol Biol Transl Sci. 2012, 106: 3-32. PMID: 22340712.
  • Jović M, Kean MJ, Szentpetery Z, Polevoy G, Gingras AC, Brill JA and Balla T. Two phosphatidylinositol 4-kinases control lysosomal delivery of the Gaucher disease enzyme, β-glucocerebrosidase. Mol Biol Cell. 2012, 23(8): 1533-45. PMID: 22337770.
  • Al-Hakim AK, Bashkurov M, Gingras AC, Durocher D and Pelletier L. Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture. Mol Cell Proteomics. 2012, 11(6): M111.014233. PMID: 22261722.

2011

  • Gingras AC. Protein phosphatases, from molecules to networks. EMBO Rep. 2011, 12(12): 1211-3. PMID: 22094273.
  • Olhovsky M, Williton K, Dai AY, Pasculescu A, Lee JP, Goudreault M, Wells CD, Park JG, Gingras AC, Linding R, Pawson T and Colwill K. OpenFreezer: a reagent information management software system. Nat Methods. 2011, 8(8): 612-3. PMID: 21799493.
  • Dunham WH, Larsen B, Tate S, Badillo BG, Goudreault M, Tehami Y, Kislinger T and Gingras AC. A cost-benefit analysis of multidimensional fractionation of affinity purification-mass spectrometry samples. Proteomics. 2011, 11(13): 2603-12. PMID: 21630450.
  • Ceccarelli DF, Laister RC, Mulligan VK, Kean MJ, Goudreault M, Scott IC, Derry WB, Chakrabartty A, Gingras AC and Sicheri F. CCM3/PDCD10 heterodimerizes with germinal center kinase III (GCKIII) proteins using a mechanism analogous to CCM3 homodimerization. J Biol Chem. 2011, 286(28): 25056-64. PMID: 21561863.
  • Kean MJ, Ceccarelli DF, Goudreault M, Sanches M, Tate S, Larsen B, Gibson LC, Derry WB, Scott IC, Pelletier L, Baillie GS, Sicheri F and Gingras AC. Structure-function analysis of core STRIPAK Proteins: a signaling complex implicated in Golgi polarization. J Biol Chem. 2011, 286(28): 25065-75. PMID: 21561862.
  • Li Z, Vizeacoumar FJ, Bahr S, Li J, Warringer J, Vizeacoumar FS, Min R, Vandersluis B, Bellay J, Devit M, Fleming JA, Stephens A, Haase J, Lin ZY, Baryshnikova A, Lu H, Yan Z, Jin K, Barker S, Datti A, Giaever G, Nislow C, Bulawa C, Myers CL, Costanzo M, Gingras AC, Zhang Z, Blomberg A, Bloom K, Andrews B and Boone C. Systematic exploration of essential yeast gene function with temperature-sensitive mutants. Nat Biotechnol. 2011, 29(4): 361-7. PMID: 21441928.
  • Skarra DV, Goudreault M, Choi H, Mullin M, Nesvizhskii AI, Gingras AC and Honkanen RE. Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5. Proteomics. 2011, 11(8): 1508-16. PMID: 21360678.
  • Templeton GW, Nimick M, Morrice N, Campbell D, Goudreault M, Gingras AC, Takemiya A, Shimazaki K and Moorhead GB. Identification and characterization of AtI-2, an Arabidopsis homologue of an ancient protein phosphatase 1 (PP1) regulatory subunit. Biochem J. 2011, 435(1): 73-83. PMID: 21222654.
  • Choi H, Larsen B, Lin ZY, Breitkreutz A, Mellacheruvu D, Fermin D, Qin ZS, Tyers M, Gingras AC and Nesvizhskii AI. SAINT: probabilistic scoring of affinity purification-mass spectrometry data. Nat Methods. 2011, 8(1): 70-3. PMID: 21131968.

2010

  • Baryshnikova A, Costanzo M, Kim Y, Ding H, Koh J, Toufighi K, Youn JY, Ou J, San Luis BJ, Bandyopadhyay S, Hibbs M, Hess D, Gingras AC, Bader GD, Troyanskaya OG, Brown GW, Andrews B, Boone C and Myers CL. Quantitative analysis of fitness and genetic interactions in yeast on a genome scale. Nat Methods. 2010, 7(12): 1017-24. PMID: 21076421.
  • O'Donnell L, Panier S, Wildenhain J, Tkach JM, Al-Hakim A, Landry MC, Escribano-Diaz C, Szilard RK, Young JT, Munro M, Canny MD, Kolas NK, Zhang W, Harding SM, Ylanko J, Mendez M, Mullin M, Sun T, Habermann B, Datti A, Bristow RG, Gingras AC, Tyers MD, Brown GW and Durocher D. The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination. Mol Cell. 2010, 40(4): 619-31. PMID: 21055983.
  • Liu G, Zhang J, Larsen B, Stark C, Breitkreutz A, Lin ZY, Breitkreutz BJ, Ding Y, Colwill K, Pasculescu A, Pawson T, Wrana JL, Nesvizhskii AI, Raught B, Tyers M and Gingras AC. ProHits: integrated software for mass spectrometry-based interaction proteomics. Nat Biotechnol. 2010, 28(10): 1015-7. PMID: 20944583.
  • Nakada S, Tai I, Panier S, Al-Hakim A, Iemura S, Juang YC, O'Donnell L, Kumakubo A, Munro M, Sicheri F, Gingras AC, Natsume T, Suda T and Durocher D. Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1. Nature. 2010, 466(7309): 941-6. PMID: 20725033.
  • Sydorskyy Y, Srikumar T, Jeram SM, Wheaton S, Vizeacoumar FJ, Makhnevych T, Chong YT, Gingras AC and Raught B. A novel mechanism for SUMO system control: regulated Ulp1 nucleolar sequestration. Mol Cell Biol. 2010, 30(18): 4452-62. PMID: 20647537.
  • Choi H, Kim S, Gingras AC and Nesvizhskii AI. Analysis of protein complexes through model-based biclustering of label-free quantitative AP-MS data. Mol Syst Biol. 2010, 6: 385. PMID: 20571534.
  • Breitkreutz A, Choi H, Sharom JR, Boucher L, Neduva V, Larsen B, Lin ZY, Breitkreutz BJ, Stark C, Liu G, Ahn J, Dewar-Darch D, Reguly T, Tang X, Almeida R, Qin ZS, Pawson T, Gingras AC, Nesvizhskii AI and Tyers M. A global protein kinase and phosphatase interaction network in yeast. Science. 2010, 328(5981): 1043-6. PMID: 20489023.
  • Bidinosti M, Ran I, Sanchez-Carbente MR, Martineau Y, Gingras AC, Gkogkas C, Raught B, Bramham CR, Sossin WS, Costa-Mattioli M, DesGroseillers L, Lacaille JC and Sonenberg N. Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission. Mol Cell. 2010, 37(6): 797-808. PMID: 20347422.
  • Mak AB, Ni Z, Hewel JA, Chen GI, Zhong G, Karamboulas K, Blakely K, Smiley S, Marcon E, Roudeva D, Li J, Olsen JB, Wan C, Punna T, Isserlin R, Chetyrkin S, Gingras AC, Emili A, Greenblatt J and Moffat J. A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency. Mol Cell Proteomics. 2010, 9(5): 811-23. PMID: 20305087.
  • Costanzo M, Baryshnikova A, Bellay J, Kim Y, Spear ED, Sevier CS, Ding H, Koh JL, Toufighi K, Mostafavi S, Prinz J, St Onge RP, VanderSluis B, Makhnevych T, Vizeacoumar FJ, Alizadeh S, Bahr S, Brost RL, Chen Y, Cokol M, Deshpande R, Li Z, Lin ZY, Liang W, Marback M, Paw J, San Luis BJ, Shuteriqi E, Tong AH, van Dyk N, Wallace IM, Whitney JA, Weirauch MT, Zhong G, Zhu H, Houry WA, Brudno M, Ragibizadeh S, Papp B, Pál C, Roth FP, Giaever G, Nislow C, Troyanskaya OG, Bussey H, Bader GD, Gingras AC, Morris QD, Kim PM, Kaiser CA, Myers CL, Andrews BJ and Boone C. The genetic landscape of a cell. Science. 2010, 327(5964): 425-31. PMID: 20093466.

2009

  • Gingras AC. Journal Club: 35 years later, mRNA caps still matter. Nat Rev Mol Cell Biol. 2009, 10(11): 734. PMID: 19866494.
  • Lawo S, Bashkurov M, Mullin M, Ferreria MG, Kittler R, Habermann B, Tagliaferro A, Poser I, Hutchins JR, Hegemann B, Pinchev D, Buchholz F, Peters JM, Hyman AA, Gingras AC and Pelletier L. HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity. Curr Biol. 2009, 19(10): 816-26. PMID: 19427217.
  • Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B and Gingras AC. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. Mol Cell Proteomics. 2009, 8(1): 157-71. PMID: 18782753.

2008

  • Nakada S, Chen GI, Gingras AC and Durocher D. PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint. EMBO Rep. 2008, 9(10): 1019-26. PMID: 18758438.
  • Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M and Gingras AC. PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4. J Biol Chem. 2008, 283(43): 29273-84. PMID: 18715871.
  • Rong L, Livingstone M, Sukarieh R, Petroulakis E, Gingras AC, Crosby K, Smith B, Polakiewicz RD, Pelletier J, Ferraiuolo MA and Sonenberg N. Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs. RNA. 2008, 14(7): 1318-27. PMID: 18515545.

2007

  • Gingras AC, Gstaiger M, Raught B and Aebersold R. Analysis of protein complexes using mass spectrometry. Nat Rev Mol Cell Biol. 2007, 8(8): 645-54. PMID: 17593931.
  • Chen GI and Gingras AC. Affinity-purification mass spectrometry (AP-MS) of serine/threonine phosphatases. Methods. 2007, 42(3): 298-305. PMID: 17532517.
  • Major MB, Camp ND, Berndt JD, Yi X, Goldenberg SJ, Hubbert C, Biechele TL, Gingras AC, Zheng N, Maccoss MJ, Angers S and Moon RT. Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling. Science. 2007, 316(5827): 1043-6. PMID: 17510365.
  • Jasavala R, Martinez H, Thumar J, Andaya A, Gingras AC, Eng JK, Aebersold R, Han DK and Wright ME. Identification of putative androgen receptor interaction protein modules: cytoskeleton and endosomes modulate androgen receptor signaling in prostate cancer cells. Mol Cell Proteomics. 2007, 6(2): 252-71. PMID: 17052974.

2005

  • Svitkin YV, Herdy B, Costa-Mattioli M, Gingras AC, Raught B and Sonenberg N. Eukaryotic translation initiation factor 4E availability controls the switch between cap-dependent and internal ribosomal entry site-mediated translation. Mol Cell Biol. 2005, 25(23): 10556-65. PMID: 16287867.
  • Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B and Aebersold R. A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. Mol Cell Proteomics. 2005, 4(11): 1725-40. PMID: 16085932.
  • Gingras AC, Aebersold R and Raught B. Advances in protein complex analysis using mass spectrometry. J Physiol. 2005, 563(Pt 1): 11-21. PMID: 15611014.

2004

  • Raught B, Peiretti F, Gingras AC, Livingstone M, Shahbazian D, Mayeur GL, Polakiewicz RD, Sonenberg N and Hershey JW. Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases. EMBO J. 2004, 23(8): 1761-9. PMID: 15071500.
  • Gingras AC, Raught B and Sonenberg N. mTOR signaling to translation. Curr Top Microbiol Immunol. 2004, 279: 169-97. PMID: 14560958.

2003

  • Zuberek J, Wyslouch-Cieszynska A, Niedzwiecka A, Dadlez M, Stepinski J, Augustyniak W, Gingras AC, Zhang Z, Burley SK, Sonenberg N, Stolarski R and Darzynkiewicz E. Phosphorylation of eIF4E attenuates its interaction with mRNA 5' cap analogs by electrostatic repulsion: intein-mediated protein ligation strategy to obtain phosphorylated protein. RNA. 2003, 9(1): 52-61. PMID: 12554876.

2002

  • Deng J, Harding HP, Raught B, Gingras AC, Berlanga JJ, Scheuner D, Kaufman RJ, Ron D and Sonenberg N. Activation of GCN2 in UV-irradiated cells inhibits translation. Curr Biol. 2002, 12(15): 1279-86. PMID: 12176355.
  • Niedzwiecka A, Marcotrigiano J, Stepinski J, Jankowska-Anyszka M, Wyslouch-Cieszynska A, Dadlez M, Gingras AC, Mak P, Darzynkiewicz E, Sonenberg N, Burley SK and Stolarski R. Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins. J Mol Biol. 2002, 319(3): 615-35. PMID: 12054859.
  • Li S, Sonenberg N, Gingras AC, Peterson M, Avdulov S, Polunovsky VA and Bitterman PB. Translational control of cell fate: availability of phosphorylation sites on translational repressor 4E-BP1 governs its proapoptotic potency. Mol Cell Biol. 2002, 22(8): 2853-61. PMID: 11909977.
  • Tang SJ, Reis G, Kang H, Gingras AC, Sonenberg N and Schuman EM. A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus. Proc Natl Acad Sci U S A. 2002, 99(1): 467-72. PMID: 11756682.

2001

  • Gingras AC, Raught B, Gygi SP, Niedzwiecka A, Miron M, Burley SK, Polakiewicz RD, Wyslouch-Cieszynska A, Aebersold R and Sonenberg N. Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes Dev. 2001, 15(21): 2852-64. PMID: 11691836.
  • Tsukiyama-Kohara K, Poulin F, Kohara M, DeMaria CT, Cheng A, Wu Z, Gingras AC, Katsume A, Elchebly M, Spiegelman BM, Harper ME, Tremblay ML and Sonenberg N. Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Nat Med. 2001, 7(10): 1128-32. PMID: 11590436.
  • Gingras AC, Raught B and Sonenberg N. Control of translation by the target of rapamycin proteins. Prog Mol Subcell Biol. 2001, 27: 143-74. PMID: 11575159.
  • Raught B, Gingras AC and Sonenberg N. The target of rapamycin (TOR) proteins. Proc Natl Acad Sci U S A. 2001, 98(13): 7037-44. PMID: 11416184.
  • Gingras AC, Raught B and Sonenberg N. Regulation of translation initiation by FRAP/mTOR. Genes Dev. 2001, 15(7): 807-26. PMID: 11297505.
  • Bhandari BK, Feliers D, Duraisamy S, Stewart JL, Gingras AC, Abboud HE, Choudhury GG, Sonenberg N and Kasinath BS. Insulin regulation of protein translation repressor 4E-BP1, an eIF4E-binding protein, in renal epithelial cells. Kidney Int. 2001, 59(3): 866-75. PMID: 11231341.

2000

  • Polunovsky VA, Gingras AC, Sonenberg N, Peterson M, Tan A, Rubins JB, Manivel JC and Bitterman PB. Translational control of the antiapoptotic function of Ras. J Biol Chem. 2000, 275(32): 24776-80. PMID: 10811643.
  • Kumar V, Sabatini D, Pandey P, Gingras AC, Majumder PK, Kumar M, Yuan ZM, Carmichael G, Weichselbaum R, Sonenberg N, Kufe D and Kharbanda S. Regulation of the rapamycin and FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase. J Biol Chem. 2000, 275(15): 10779-87. PMID: 10753870.
  • Raught B, Gingras AC, Gygi SP, Imataka H, Morino S, Gradi A, Aebersold R and Sonenberg N. Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI. EMBO J. 2000, 19(3): 434-44. PMID: 10654941.

1999

  • Gingras AC, Raught B and Sonenberg N. eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem. 1999, 68: 913-63. PMID: 10872469.
  • Takata M, Ogawa W, Kitamura T, Hino Y, Kuroda S, Kotani K, Klip A, Gingras AC, Sonenberg N and Kasuga M. Requirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1). J Biol Chem. 1999, 274(29): 20611-8. PMID: 10400692.
  • Marcotrigiano J, Gingras AC, Sonenberg N and Burley SK. Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G. Mol Cell. 1999, 3(6): 707-16. PMID: 10394359.
  • Gingras AC, Gygi SP, Raught B, Polakiewicz RD, Abraham RT, Hoekstra MF, Aebersold R and Sonenberg N. Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes Dev. 1999, 13(11): 1422-37. PMID: 10364159.
  • Khaleghpour K, Pyronnet S, Gingras AC and Sonenberg N. Translational homeostasis: eukaryotic translation initiation factor 4E control of 4E-binding protein 1 and p70 S6 kinase activities. Mol Cell Biol. 1999, 19(6): 4302-10. PMID: 10330171.
  • Raught B and Gingras AC. eIF4E activity is regulated at multiple levels. Int J Biochem Cell Biol. 1999, 31(1): 43-57. PMID: 10216943.
  • Rao GN, Madamanchi NR, Lele M, Gadiparthi L, Gingras AC, Eling TE and Sonenberg N. A potential role for extracellular signal-regulated kinases in prostaglandin F2alpha-induced protein synthesis in smooth muscle cells. J Biol Chem. 1999, 274(18): 12925-32. PMID: 10212283.
  • Gygi SP, Han DK, Gingras AC, Sonenberg N and Aebersold R. Protein analysis by mass spectrometry and sequence database searching: tools for cancer research in the post-genomic era. Electrophoresis. 1999, 20(2): 310-9. PMID: 10197438.
  • Pyronnet S, Imataka H, Gingras AC, Fukunaga R, Hunter T and Sonenberg N. Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. EMBO J. 1999, 18(1): 270-9. PMID: 9878069.

1998

  • Polakiewicz RD, Schieferl SM, Gingras AC, Sonenberg N and Comb MJ. mu-Opioid receptor activates signaling pathways implicated in cell survival and translational control. J Biol Chem. 1998, 273(36): 23534-41. PMID: 9722592.
  • Svitkin YV, Hahn H, Gingras AC, Palmenberg AC and Sonenberg N. Rapamycin and wortmannin enhance replication of a defective encephalomyocarditis virus. J Virol. 1998, 72(7): 5811-9. PMID: 9621041.
  • Pyronnet S, Gingras AC, Bouisson M, Kowalski-Chauvel A, Seva C, Vaysse N, Sonenberg N and Pradayrol L. Gastrin induces phosphorylation of eIF4E binding protein 1 and translation initiation of ornithine decarboxylase mRNA. Oncogene. 1998, 16(17): 2219-27. PMID: 9619831.
  • Poulin F, Gingras AC, Olsen H, Chevalier S and Sonenberg N. 4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family. J Biol Chem. 1998, 273(22): 14002-7. PMID: 9593750.
  • Rom E, Kim HC, Gingras AC, Marcotrigiano J, Favre D, Olsen H, Burley SK and Sonenberg N. Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein. J Biol Chem. 1998, 273(21): 13104-9. PMID: 9582349.
  • Sonenberg N and Gingras AC. The mRNA 5' cap-binding protein eIF4E and control of cell growth. Curr Opin Cell Biol. 1998, 10(2): 268-75. PMID: 9561852.
  • Beretta L, Singer NG, Hinderer R, Gingras AC, Richardson B, Hanash SM and Sonenberg N. Differential regulation of translation and eIF4E phosphorylation during human thymocyte maturation. J Immunol. 1998, 160(7): 3269-73. PMID: 9531283.
  • Sonenberg N, Burley SK and Gingras AC. RNA chiropractics. Nat Struct Biol. 1998, 5(3): 172-4. PMID: 9501904.
  • Gingras AC, Kennedy SG, O'Leary MA, Sonenberg N and Hay N. 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev. 1998, 12(4): 502-13. PMID: 9472019.
  • Fletcher CM, McGuire AM, Gingras AC, Li H, Matsuo H, Sonenberg N and Wagner G. 4E binding proteins inhibit the translation factor eIF4E without folded structure. Biochemistry. 1998, 37(1): 9-15. PMID: 9453748.

1997

  • Marcotrigiano J, Gingras AC, Sonenberg N and Burley SK. X-ray studies of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP. Nucleic Acids Symp Ser. 1997, 8-11. PMID: 9478191.
  • Gingras AC and Sonenberg N. Adenovirus infection inactivates the translational inhibitors 4E-BP1 and 4E-BP2. Virology. 1997, 237(1): 182-6. PMID: 9344920.
  • Matsuo H, Li H, McGuire AM, Fletcher CM, Gingras AC, Sonenberg N and Wagner G. Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein. Nat Struct Biol. 1997, 4(9): 717-24. PMID: 9302999.
  • von Manteuffel SR, Dennis PB, Pullen N, Gingras AC, Sonenberg N and Thomas G. The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70s6k. Mol Cell Biol. 1997, 17(9): 5426-36. PMID: 9271419.
  • Marcotrigiano J, Gingras AC, Sonenberg N and Burley SK. Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP. Cell. 1997, 89(6): 951-61. PMID: 9200613.
  • Aronica SM, Gingras AC, Sonenberg N, Cooper S, Hague N and Broxmeyer HE. Macrophage inflammatory protein-1alpha and interferon-inducible protein 10 inhibit synergistically induced growth factor stimulation of MAP kinase activity and suppress phosphorylation of eukaryotic initiation factor 4E and 4E binding protein 1. Blood. 1997, 89(10): 3582-95. PMID: 9160663.
  • Fleurent M, Gingras AC, Sonenberg N and Meloche S. Angiotensin II stimulates phosphorylation of the translational repressor 4E-binding protein 1 by a mitogen-activated protein kinase-independent mechanism. J Biol Chem. 1997, 272(7): 4006-12. PMID: 9020107.

1996

  • Tsukiyama-Kohara K, Vidal SM, Gingras AC, Glover TW, Hanash SM, Heng H and Sonenberg N. Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2. Genomics. 1996, 38(3): 353-63. PMID: 8975712.
  • Rousseau D, Gingras AC, Pause A and Sonenberg N. The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth. Oncogene. 1996, 13(11): 2415-20. PMID: 8957083.
  • Raught B, Gingras AC, James A, Medina D, Sonenberg N and Rosen JM. Expression of a translationally regulated, dominant-negative CCAAT/enhancer-binding protein beta isoform and up-regulation of the eukaryotic translation initiation factor 2alpha are correlated with neoplastic transformation of mammary epithelial cells. Cancer Res. 1996, 56(19): 4382-6. PMID: 8813130.
  • Whalen SG, Gingras AC, Amankwa L, Mader S, Branton PE, Aebersold R and Sonenberg N. Phosphorylation of eIF-4E on serine 209 by protein kinase C is inhibited by the translational repressors, 4E-binding proteins. J Biol Chem. 1996, 271(20): 11831-7. PMID: 8662663.
  • Gingras AC, Svitkin Y, Belsham GJ, Pause A and Sonenberg N. Activation of the translational suppressor 4E-BP1 following infection with encephalomyocarditis virus and poliovirus. Proc Natl Acad Sci U S A. 1996, 93(11): 5578-83. PMID: 8643618.
  • von Manteuffel SR, Gingras AC, Ming XF, Sonenberg N and Thomas G. 4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase. Proc Natl Acad Sci U S A. 1996, 93(9): 4076-80. PMID: 8633019.
  • Beretta L, Gingras AC, Svitkin YV, Hall MN and Sonenberg N. Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation. EMBO J. 1996, 15(3): 658-64. PMID: 8599949.

1994

  • Pause A, Belsham GJ, Gingras AC, Donzé O, Lin TA, Lawrence JC Jr and Sonenberg N. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function. Nature. 1994, 371(6500): 762-7. PMID: 7935836.